CPA1 anticorps

N° du produit ABIN6937013

Cet anticorps Souris Monoclonal détecte spécifiquement CPA1 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CPA1 anticorps (ABIN6937013)

Antigène: CPA1 (Carboxypeptidase A1 (Pancreatic) (CPA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CPA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CPA1-2711

Détail du produit anti-CPA1 anticorps

Fonction: Carboxypeptidase A1 / CPA1 (Pancreatic Cancer Marker) Antibody

Specificité: Human pancreatic procarboxypeptidase A exists as three different active forms, two of which are designated carboxypeptidase A1 (CPA1) and carboxypeptidase A2 (CPA2). CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogène: Recombinant full-length human CPA1 protein

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: Pancreas. Pancreas tissue lysate.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CPA1

Antigène: CPA1 (Carboxypeptidase A1 (Pancreatic) (CPA1))

Autre désignation: CPA1

Sujet:

Carboxypeptidase A1 (pancreatic), CPA1, Pancreatic Carboxypeptidase A1, Procarboxypeptidase A1 pancreatic

Pancreas. Pancreas tissue lysate.

Poids moléculaire: 47kDa

ID gène: 1357, 2879

UniProt: P15085