CTLA4 anticorps
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- Antigène Voir toutes CTLA4 Anticorps
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CTLA4 est non-conjugé
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Application
- Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF)
- Specificité
- CTLA4 (CD152) is a cell surface receptor that behaves as a negative regulator of the proliferation and the effector function of T cells. It contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.The novel finding that CTLA-4 Molecule is expressed and functional on human tumor cells opens up the possibility of antitumor therapeutic intervention based on targeting this molecule.
- Réactivité croisée (Details)
- Cow, Cat, Mouse and Rat. Does not react with Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- A synthetic peptide from CTLA4 (exact sequence is proprietary)
- Clone
- L4P2F5-F10
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CTLA4 Anticorps primaire
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- Indications d'application
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Known_Application: Flow Cytometry (1-2 μg/million cells), ,Immunofluorescence (1-2 μg/mL), ,Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: Jurkat or Raji cells. Lymph node or tonsil.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
- Autre désignation
- CTLA4 (CTLA4 Produits)
- Synonymes
- anticorps CTLA-4, anticorps CTLA4, anticorps CD152, anticorps Cd152, anticorps Ctla-4, anticorps Ly-56, anticorps CD, anticorps CELIAC3, anticorps GRD4, anticorps GSE, anticorps IDDM12, anticorps sCTLA4, anticorps cytotoxic T-lymphocyte associated protein 4, anticorps cytotoxic T-lymphocyte-associated protein 4, anticorps CTLA4, anticorps Ctla4
- Sujet
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ALPS5, CD152, Celiac disease 3 (CELIAC3), Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), GRD4, GSE, ICOS, Insulin-dependent Diabetes Mellitus 12 (IDDM12),CTLA4 / CD152 (Negative Regulator of T-Cells)
Cellular localisation: Cell surface. Secreted. - Poids moléculaire
- 30-43kDa
- ID gène
- 1493, 247824
- UniProt
- P16410
- Pathways
- Cancer Immune Checkpoints
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