Cathepsin D anticorps (AA 104-250)

N° du produit ABIN6937054

Détail du produit anti-Cathepsin D anticorps

Antigène: Cathepsin D (CTSD)

Épitope: AA 104-250

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)

Clone: CTSD-2781

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K-562, MCF-7 or SK-BR3 cells. Human kidney, liver, lung or breast tissues.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Cathepsin D

Antigène: Cathepsin D (CTSD)

Autre désignation: CTSD (CTSD Produits)

Synonymes: anticorps catD, anticorps fb93e11, anticorps fj17b09, anticorps wu:fb93e11, anticorps wu:fj17b09, anticorps LOC398557, anticorps Cathd, anticorps CatD, anticorps LOC100136761, anticorps CTSD, anticorps DKFZp469J0315, anticorps DDBDRAFT_0205785, anticorps DDBDRAFT_0215012, anticorps DDB_0205785, anticorps DDB_0215012, anticorps CLN10, anticorps CPSD, anticorps CD, anticorps cathepsin D, anticorps cathepsin D S homeolog, anticorps lysosomal aspartic protease, anticorps cathepsin D-like, anticorps ctsd, anticorps LOC398557, anticorps ctsd.S, anticorps CatD, anticorps LOC5567565, anticorps LOC100136761, anticorps CTSD, anticorps Cathd, anticorps ctsD, anticorps catd, anticorps Ctsd, anticorps LOC443060

Sujet: CatD, Cathepsin D, Ceroid lipofuscinosis neuronal 10, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease,Cathepsin D (Tumor Marker)
Cellular localisation: Cytoplasmic

Poids moléculaire: 48kDa (Procathepsin D), 34kDa (Cathepsin D), 14kDa (Cathepsin D)

ID gène: 1509, 654447

UniProt: P07339

Pathways: Peptide Hormone Metabolism