DBN1 anticorps (AA 150-281)

N° du produit ABIN6937083

Détail du produit anti-DBN1 anticorps

Antigène: DBN1 (Drebrin 1 (DBN1))

Épitope: AA 150-281

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DBN1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Drebrins (developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2), and an adult type (A), generated by alternative RNA splicing from a single Drebrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain have been been associated with Alzheimer s disease and Down syndrome.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (aa 150-281) of human DBN1 protein (exact sequence is proprietary)

Clone: DBN1-2879

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: PC3 cells. Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur DBN1

Antigène: DBN1 (Drebrin 1 (DBN1))

Autre désignation: DBN1 (DBN1 Produits)

Synonymes: anticorps D0S117E, anticorps DBN1, anticorps LOC733967, anticorps drebrin 1, anticorps drebrin 1 S homeolog, anticorps DBN1, anticorps Dbn1, anticorps dbn1.S, anticorps dbn1

Sujet: Developmentally regulated brain protein, Drebrin 1, Drebrin, Drebrin E, Drebrin E2, Drebrin1, DrebrinE,Drebrin 1 (DBN1)
Cellular localisation: Cytoplasmic

Poids moléculaire: 120kDa

ID gène: 1627, 130316

UniProt: Q16643

Pathways: Maintenance of Protein Location