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Desmoglein 2 anticorps

DSG2 Reactivité: Humain WB, IF, FACS Hôte: Souris Monoclonal 6D8 unconjugated
N° du produit ABIN6937110
  • Antigène Voir toutes Desmoglein 2 (DSG2) Anticorps
    Desmoglein 2 (DSG2)
    Reactivité
    • 89
    • 37
    • 34
    • 7
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 72
    • 17
    Souris
    Clonalité
    • 63
    • 26
    Monoclonal
    Conjugué
    • 42
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Desmoglein 2 est non-conjugé
    Application
    • 76
    • 26
    • 22
    • 17
    • 15
    • 13
    • 13
    • 13
    • 10
    • 6
    • 6
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
    Specificité
    Recognizes a protein of 165 kDa, identified as Desmoglein-2 (DSG2). This monoclonal antibody recognizes the extracellular domain of human desmoglein-2. Desmoglein-2 is a member of the desmosomal cadherin family. Desmosomesare intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Human Desmoglein-2 is a type I transmembrane glycoprotein of 1117 amino acid (aa) residues with a 23 aa signal peptide and a 25 aa propeptide. It differs from other classic cadherins by having four instead of five cadherin repeat domains in its extracellular region, and a much larger cytoplasmic region containing five desmoglein repeat domains which share homology with the cadherin repeats. Instead of having the HAV adhesion motif found in type I cadherins, desmogleins have R/YAL as the adhesion motif on its amino-terminal cadherin repeat. The cytoplasmic tails of desmogleins interact with desmoplakins, plakoglobin and plakophilins. In turn, these proteins link the desmogleins with the intermediate filaments. Desmoglein-2 has been shown to be important in establishing cell-cell adhesion and function in epithelial cells. Desmoglein2 was originally identified in colon carcinoma and colon, and was named HDGC (human desmoglein colon).
    Réactivité croisée (Details)
    Human.
    Purification
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogène
    Recombinant human DSG2 protein
    Clone
    6D8
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product DSG2 Anticorps primaire
  • Indications d'application

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL) Optimal dilution for a specific application should be determined.

    Positive_Control: A431, HepG2 or K562 cells. Heart or Colon.

    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Agent conservateur
    Azide free
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Date de péremption
    24 months
  • Antigène
    Desmoglein 2 (DSG2)
    Autre désignation
    DSG2 (DSG2 Produits)
    Synonymes
    anticorps DSG2, anticorps dsc, anticorps dsga, anticorps si:dkeyp-51f12.6, anticorps wu:fj23f02, anticorps ARVC10, anticorps ARVD10, anticorps CDHF5, anticorps CMD1BB, anticorps HDGC, anticorps AA408168, anticorps D18Ertd293e, anticorps desmoglein 2, anticorps desmoglein 2, tandem duplicate 1, anticorps DSG2, anticorps dsg2.1, anticorps dsg2, anticorps Dsg2
    Sujet
    ARVC10, ARVD10, Cadherin family member 5, CDHF5, CMD1BB, Desmoglein-2, DSG2, HDGC, Human Desmoglein Colon,Desmoglein-2 (DSG2)
    Cellular localisation: Cell surface
    Poids moléculaire
    165kDa
    ID gène
    1829, 412597
    UniProt
    Q14126
    Pathways
    Cell-Cell Junction Organization
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