Emerin anticorps (AA 56-167)

N° du produit ABIN6937145

Cet anticorps Souris Monoclonal détecte spécifiquement Emerin dans WB, IF et IHC (f). Il présente une réactivité envers Humain.

Aperçu rapide pour Emerin anticorps (AA 56-167) (ABIN6937145)

Antigène: Emerin (EMD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Emerin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: EMD-2167

Détail du produit anti-Emerin anticorps

Épitope: AA 56-167

Specificité: Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant human Emerin protein fragment (around aa 56-167) (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Immunofluorescence (1-3 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K-562, HeLa or Jurkat cells. Kidney or Skin.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Emerin

Antigène: Emerin (EMD)

Autre désignation: EMD

Sujet: EMD, Emerin, Emery Dreifuss muscular dystrophy (EDMD), STA,Emerin (Papillary Thyroid Carcinoma and EDMD Marker)
Cellular localisation: Nuclear Membrane

Poids moléculaire: 37kDa

ID gène: 2010, 522823

UniProt: P50402