ERCC1 anticorps (AA 191-281)

N° du produit ABIN6937182

L’anticorps Souris Monoclonal anti-ERCC1 a été validé pour WB, ELISA et Coat. Il convient pour détecter ERCC1 dans des échantillons de Humain.

Aperçu rapide pour ERCC1 anticorps (AA 191-281) (ABIN6937182)

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ERCC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Coating (Coat)

Clone: ERCC1-2318

Détail du produit anti-ERCC1 anticorps

Épitope: AA 191-281

Specificité: Recognizes a protein of 110 kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 191-281) of human ERCC1 protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order antibody without BSA),Western Blot (1-2 μg/mL),Optimal dilution for a specific application should be determined.Optimal dilution for a specific application should be determined.

Positive_Control: HeLa or HepG2 cells. Tonsil or Prostate.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur ERCC1

Antigène: ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))

Autre désignation: ERCC1

Sujet: COFS4, DNA excision repair protein ERCC1, ERCC1, Excision repair cross complementing 1, RAD10, UV20,ERCC1 / RAD10 (Tumor Progression Marker)
Cellular localisation: Nuclear

Poids moléculaire: 110kDa

ID gène: 2067, 435981

UniProt: P07992

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response