Fascin anticorps

N° du produit ABIN6937267

Détail du produit anti-Fascin anticorps

Antigène: Fascin (FSCN1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Fascin est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: Recognizes a protein of 55kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

Réactivité croisée (Details): Human. Rat.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Full length recombinant human FSCN1 protein

Clone: FSCN1-418

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2ug/ml); Flow Cytometry (1-2ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 1mM EDTA, pH 8.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Positive_Control: K562, HeLa, MCF-7, PC-3 or BEWO cells. Hodgkin's lymphoma, Ovarian or Testicular Carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Fascin

Antigène: Fascin (FSCN1)

Autre désignation: FSCN1 (FSCN1 Produits)

Synonymes: anticorps CG15331, anticorps CG1536, anticorps CG32858, anticorps Dmel\\CG32858, anticorps SN, anticorps Sn, anticorps fs(1)A1057, anticorps fs(1)K1421, anticorps fs(1)K418, anticorps fs(1)K473, anticorps fs(1)K743, anticorps fs(1)M45, anticorps p55, anticorps snl, anticorps MGC75811, anticorps fscn1, anticorps sb:cb589, anticorps zgc:153632, anticorps AI663989, anticorps Fan1, anticorps fascin-1, anticorps Fascin, anticorps fscn, anticorps FAN1, anticorps HSN, anticorps SNL, anticorps fascin, anticorps singed, anticorps fascin actin-bundling protein 1, anticorps fascin actin-bundling protein 1a, anticorps fascin actin-bundling protein 1 L homeolog, anticorps sn, anticorps fscn1, anticorps fscn1a, anticorps Fscn1, anticorps fscn1.L, anticorps FSCN1

Sujet: 55 kDa actin-bundling protein, FAN1, Fascin homolog 1, Fascin1, FSCN1, HSN, p55, Singed (Drosophila) like (sea urchin fascin homolog like), SNL,Fascin-1 (Reed-Sternberg Cell Marker)
Cellular localisation: Cytoplasmic

Poids moléculaire: 55kDa

ID gène: 6624, 118400

UniProt: Q16658