HLA-B anticorps

N° du produit ABIN6937395

Détail du produit anti-HLA-B anticorps

Antigène: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HLA-B est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Specificité: This MAb recognizes the HLA-B27 cell surface antigen on human cells. It may be used to HLA type human lymphocytes. Approximately 60 % of patients with ankylosing spondylitis are HLA-B27 positive. This reagent can be used to help identify this HLA haplotype in human lymphocytes. Major histocompatibility complex (MHC) molecules form an integral part of the immune response system. They are cell-surface receptors that bind pep- tides and present them to T lymphocytes. Human leukocyte antigens (HLAs) are polymorphic members of the MHC family that are specifically involved in the presentation of antigens to the T cell receptor. There are two classes of HLA antigens: class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). Class I molecules are expressed in nearly all cells and play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes. HLA-B encodes a membrane anchored heavy chain, which hetero-dimerizes with a light chain (-2-Microglobulin) to form MHC-I. Polymorphisms yield hundreds of HLA-B alleles. The HLA-B27 allele appears with increased frequency in uveitis patients.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Lymphocytes from an HLA-B27 patient

Clone: EP-4

Isotype: IgM kappa

Information d'application

Indications d'application:

Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Human peripheral blood lymphocytes, tonsil or lymph node.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Purified Ab WITHOUT BSA at 1.0mg/ml

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur HLA-B

Antigène: HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))

Autre désignation: HLA-B (HLA-B Produits)

Synonymes: anticorps AS, anticorps HLAB, anticorps SPDA1, anticorps mhc1b, anticorps major histocompatibility complex, class I, B, anticorps major histocompatibility complex nonclassical class Ib L homeolog, anticorps HLA-B, anticorps BOLA-B, anticorps MAMU-B18, anticorps DKFZP469N1225, anticorps mhc1b.L

Sujet: HLA-B, HLAB, MHC Class I HLA heavy chain, Leukocyte antigen class I-B,HLA-B (MHC Class I)
Cellular localisation: Cell Surface

Poids moléculaire: 30kDa

ID gène: 3106, 77961

UniProt: P03989

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints