NKX2-1 anticorps
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- Antigène Voir toutes NKX2-1 Anticorps
- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
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Reactivité
- Rat
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp NKX2-1 est non-conjugé
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- Recognizes a protein of 40 kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
- Réactivité croisée (Details)
- Human. Mouse. Rat. Shows a broad species reactivity.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Rat full length TTF-1 recombinant protein
- Clone
- 8G7G3-1
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product NKX2-1 Anticorps primaire
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- Indications d'application
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: MAD109, MLE-15, H441-4 or H345 cells. Normal thyroid or lung.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- NKX2-1 (NK2 Homeobox 1 (NKX2-1))
- Autre désignation
- NKX2-1 (NKX2-1 Produits)
- Synonymes
- anticorps BCH, anticorps BHC, anticorps NK-2, anticorps NKX2.1, anticorps NKX2A, anticorps TEBP, anticorps TITF1, anticorps TTF-1, anticorps TTF1, anticorps titf1-A, anticorps Xnkx-2.1, anticorps NKX2-1, anticorps LOC100227803, anticorps AV026640, anticorps Nkx2.1, anticorps T/EBP, anticorps Titf1, anticorps Ttf-1, anticorps nk2.1a, anticorps nkx2.1, anticorps nkx2.4a, anticorps titf1, anticorps titf1a, anticorps NK2 homeobox 1, anticorps NK2 homeobox 1 L homeolog, anticorps NK2 homeobox 4b, anticorps NKX2-1, anticorps nkx2-1.L, anticorps Nkx2-1, anticorps nkx2.4b
- Sujet
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BCH, Benign chorea, BHC, Homeobox protein Nkx2.1, NK2 homeobox 1, NKX2.1, NKX2A, TEBP, Thyroid nuclear factor-1, Thyroid specific enhancer binding protein, Thyroid transcription factor-1 (TTF-1), Tin man, TITF1, TTF-1,TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker)
Cellular localisation: Nuclear - Poids moléculaire
- 40kDa
- ID gène
- 7080, 94367
- UniProt
- P43699
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Glucan Metabolic Process, Feeding Behaviour
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