ORC1 anticorps
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- Antigène Voir toutes ORC1 (ORC1L) Anticorps
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp ORC1 est non-conjugé
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Application
- ELISA, Coating (Coat)
- Specificité
- The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle, however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.
- Réactivité croisée (Details)
- Human.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant full-length human ORC1 protein
- Clone
- 7F6-1
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product ORC1L Anticorps primaire
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- Indications d'application
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Known_Application: ELISA (For coating, order antibody without BSA)Optimal dilution for a specific application should be determined.
Positive_Control: HeLa cells.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
- Autre désignation
- ORC1L (ORC1L Produits)
- Synonymes
- anticorps CG10667, anticorps DmORC1, anticorps DmOrc1, anticorps DmOrc1p, anticorps Dmel\\CG10667, anticorps ORC, anticorps ORC1, anticorps dORC1, anticorps orc1, anticorps rDmORC, anticorps ORC1L, anticorps HSORC1, anticorps PARC1, anticorps orc1l, anticorps xorc1, anticorps AA545195, anticorps MmORC1, anticorps Orc1l, anticorps Origin recognition complex subunit 1, anticorps origin recognition complex subunit 1, anticorps origin recognition complex subunit 1 L homeolog, anticorps origin recognition complex, subunit 1, anticorps Orc1, anticorps ORC1, anticorps orc1.L
- Sujet
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HSORC1, MmORC1, Origin Recognition Complex 1 (ORC1), Origin recognition complex subunit 1 (yeast homolog) like (ORC1L), Origin recognition complex subunit 1 like (S. cerevisia, Origin recognition complex subunit 1 like, PARC1, Replication control protein 1,ORC1
Cellular localisation: Nucleus. - Poids moléculaire
- 120kDa
- ID gène
- 4998, 17908
- UniProt
- Q13415
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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