ORC1 anticorps
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- Antigène Voir toutes ORC1 (ORC1L) Anticorps
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
- Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp ORC1 est non-conjugé
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Application
- ELISA, Immunohistochemistry (IHC)
- Attributs du produit
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogène
- Fusion protein of human ORC1
- Isotype
- IgG
- Top Product
- Discover our top product ORC1L Anticorps primaire
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- Indications d'application
- IHC 1:50-1:300, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.14 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))
- Autre désignation
- ORC1 (ORC1L Produits)
- Synonymes
- anticorps CG10667, anticorps DmORC1, anticorps DmOrc1, anticorps DmOrc1p, anticorps Dmel\\CG10667, anticorps ORC, anticorps ORC1, anticorps dORC1, anticorps orc1, anticorps rDmORC, anticorps ORC1L, anticorps HSORC1, anticorps PARC1, anticorps orc1l, anticorps xorc1, anticorps AA545195, anticorps MmORC1, anticorps Orc1l, anticorps Origin recognition complex subunit 1, anticorps origin recognition complex subunit 1, anticorps origin recognition complex subunit 1 L homeolog, anticorps origin recognition complex, subunit 1, anticorps Orc1, anticorps ORC1, anticorps orc1.L
- Sujet
- The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.ORC1 (Origin Recognition Complex Subunit 1) is a Protein Coding gene. Diseases associated with ORC1 include Meier-Gorlin Syndrome 1 and Microtia. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include chromatin binding. An important paralog of this gene is CDC6.
- UniProt
- Q13415
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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