SERBP1 anticorps (AA 3-139)

N° du produit ABIN6938368

Cet anticorps anti-SERBP1 Monoclonal Souris (Clone SERBP1-3491) (ABIN6938368) détecte spécifiquement SERBP1 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour SERBP1 anticorps (AA 3-139) (ABIN6938368)

Antigène: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SERBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: SERBP1-3491

Détail du produit anti-SERBP1 anticorps

Épitope: AA 3-139

Fonction: SERBP1 / PAI-RBP1 Antibody

Specificité: SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-°™ and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.

Réactivité croisée (Details): Human.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K562 or PC3 cells. Human kidney or bladder tissue (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur SERBP1

Antigène: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Autre désignation: SERBP1

Sujet:

CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1

K562 or PC3 cells. Human kidney or bladder tissue (IHC).

Poids moléculaire: 60kDa

ID gène: 26135, 530412

UniProt: Q8NC51