SERBP1 anticorps (AA 3-139)

N° du produit ABIN6938369

Détail du produit anti-SERBP1 anticorps

Antigène: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Épitope: AA 3-139

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SERBP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Specificité: SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-i± and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone’s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)

Clone: SERBP1-3493

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

Positive_Control: K562 or PC3 cells. Human kidney or bladder tissue (IHC).

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur SERBP1

Antigène: SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

Autre désignation: SERBP1 (SERBP1 Produits)

Synonymes: anticorps CHD3IP, anticorps HABP4L, anticorps PAI-RBP1, anticorps PAIRBP1, anticorps 1200009K13Rik, anticorps 9330147J08Rik, anticorps AL022786, anticorps Pairbp1, anticorps Pai-Rbp1, anticorps Rda288, anticorps cgi-55, anticorps chd3ip, anticorps habp4l, anticorps pai-rbp1, anticorps pairbp1, anticorps rda288, anticorps hm:zeh0245, anticorps serbp1, anticorps wu:fa12d05, anticorps wu:fb36e07, anticorps wu:fc16f12, anticorps wu:fj13e12, anticorps zgc:55489, anticorps SERPINE1 mRNA binding protein 1, anticorps serpine1 mRNA binding protein 1, anticorps Serpine1 mRNA binding protein 1, anticorps SERPINE1 mRNA binding protein 1 L homeolog, anticorps SERPINE1 mRNA binding protein 1a, anticorps SERBP1, anticorps Serbp1, anticorps serbp1.L, anticorps serbp1a

Sujet: CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1,SERBP1 / PAI-RBP1
Cellular localisation: Cytoplasm and nucleus. Also found in perinuclear regions.

Poids moléculaire: 60kDa

ID gène: 26135, 530412

UniProt: Q8NC51