SERBP1 anticorps (AA 3-139)
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- Antigène Voir toutes SERBP1 Anticorps
- SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
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Épitope
- AA 3-139
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SERBP1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Specificité
- SERBP1 is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. It is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, SERBP1 interacts with Mi2-i± and may be involved in chromatin remodeling. It also interacts with PGRMC1 and participates in the transduction of Progesterone s antiapoptotic action in ovarian cell types. SERBP1 is overexpressed in ovarian cancer, suggesting a possible role in tumorigenesis and tumor metastasis.
- Réactivité croisée (Details)
- Human. Others not tested.
- Purification
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogène
- Recombinant fragment of human SERBP1 protein (around aa3-139) (exact sequence is proprietary)
- Clone
- SERBP1-3496
- Isotype
- IgG2c kappa
- Top Product
- Discover our top product SERBP1 Anticorps primaire
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- Indications d'application
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Known_Application: Western Blot (1-2 μg/mL), ,Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: K562 or PC3 cells. Human kidney or bladder tissue (IHC).
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Agent conservateur
- Azide free
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Date de péremption
- 24 months
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- Antigène
- SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
- Autre désignation
- SERBP1 (SERBP1 Produits)
- Synonymes
- anticorps CHD3IP, anticorps HABP4L, anticorps PAI-RBP1, anticorps PAIRBP1, anticorps 1200009K13Rik, anticorps 9330147J08Rik, anticorps AL022786, anticorps Pairbp1, anticorps Pai-Rbp1, anticorps Rda288, anticorps cgi-55, anticorps chd3ip, anticorps habp4l, anticorps pai-rbp1, anticorps pairbp1, anticorps rda288, anticorps hm:zeh0245, anticorps serbp1, anticorps wu:fa12d05, anticorps wu:fb36e07, anticorps wu:fc16f12, anticorps wu:fj13e12, anticorps zgc:55489, anticorps SERPINE1 mRNA binding protein 1, anticorps serpine1 mRNA binding protein 1, anticorps Serpine1 mRNA binding protein 1, anticorps SERPINE1 mRNA binding protein 1 L homeolog, anticorps SERPINE1 mRNA binding protein 1a, anticorps SERBP1, anticorps Serbp1, anticorps serbp1.L, anticorps serbp1a
- Sujet
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CGI 55, CHD3IP, Chromodomain helicase DNA binding protein 3 interacting protein, HABP4L, PAI1 RNA-binding protein 1, PAIRBP1, Plasminogen activator inhibitor 1 RNA binding protein, SERPINE1 mRNA binding protein 1,SERBP1 / PAI-RBP1
Cellular localisation: Cytoplasm and nucleus. Also found in perinuclear regions. - Poids moléculaire
- 60kDa
- ID gène
- 26135, 530412
- UniProt
- Q8NC51
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