Transferrin Receptor anticorps (AA 94-212)

N° du produit ABIN6938531

Cet anticorps Souris Monoclonal détecte spécifiquement Transferrin Receptor dans WB, ELISA, Coat et IHC (f). Il présente une réactivité envers Humain.

Aperçu rapide pour Transferrin Receptor anticorps (AA 94-212) (ABIN6938531)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: TFRC-1817

Détail du produit anti-Transferrin Receptor anticorps

Épitope: AA 94-212

Specificité: It recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant extracellular fragment (around aa 94-212) of human TFRC protein (exact sequence is proprietary)

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: Jurkat, HeLa, MCF-7 or K562 cells. Human placenta or Bone Marrow.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: TFRC

Sujet: Mtvr-1, p90, TFR1, TFRC transferrin receptor (p90 CD71), TRFR,CD71 / Transferrin Receptor (TFRC) (Extracellular Domain)
Cellular localisation: Cell surface

Poids moléculaire: 85-95kDa (monomer), 190kDa (dimer)

ID gène: 7037, 529618

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis