Recombinant Thyroglobulin anticorps

N° du produit ABIN6938559

L’anticorps Souris Monoclonal anti-Thyroglobulin a été validé pour IHC et StM. Il convient pour détecter Thyroglobulin dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant Thyroglobulin anticorps (ABIN6938559)

Antigène: Thyroglobulin (TG)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroglobulin est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: R2H11

Détail du produit anti-Thyroglobulin anticorps

Specificité: MAb r2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

Purification: Purified by Protein A/G

Immunogène: Human thyroid follicular cells

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: Thyroid.

Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL, 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Buffer: 10 mM PBS without BSA and without Azide.

Agent conservateur: Azide free

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months.

Date de péremption: 24 months

Détails sur Thyroglobulin

Antigène: Thyroglobulin (TG)

Autre désignation: Thyroglobulin (Thyroidal Cell Marker)

Poids moléculaire: 660kDa (Dimeric Form)

ID gène: 7038

UniProt: P01266

Pathways: Thyroid Hormone Synthesis