TOX3 anticorps (AA 251-389)

N° du produit ABIN6938637

L’anticorps Souris Monoclonal anti-TOX3 a été validé pour WB, ELISA et Coat. Il convient pour détecter TOX3 dans des échantillons de Humain.

Aperçu rapide pour TOX3 anticorps (AA 251-389) (ABIN6938637)

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOX3 est non-conjugé

Application: Western Blotting (WB), ELISA, Coating (Coat)

Clone: TOX3-1124

Détail du produit anti-TOX3 anticorps

Épitope: AA 251-389

Specificité: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Positive_Control: SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur TOX3

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Autre désignation: TOX3

Sujet: TOX3, CAG trinucleotide repeat-containing gene F9 protein, CAGF9, TOX high mobility group box family member 3, Trinucleotide repeat containing 9 (TNRC9),TOX3 / TNRC9
Cellular localisation: Cytoplasmic & Nuclear

Poids moléculaire: 63kDa

ID gène: 27324, 460789

UniProt: O15405

Pathways: Chromatin Binding