Chromogranin A anticorps

N° du produit ABIN6939126

Cet anticorps anti-Chromogranin A est un anticorps Souris Monoclonal détectant Chromogranin A dans IHC et StM. Adapté pour Humain, Rat, Souris, Singe et Porc.

Aperçu rapide pour Chromogranin A anticorps (ABIN6939126)

Antigène: Chromogranin A (CHGA)

Reactivité: Humain, Rat, Souris, Singe, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Chromogranin A est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: LK2H10

Détail du produit anti-Chromogranin A anticorps

Specificité: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Aucune reactivité croisée: Cobaye, Lapin, Mouton

Purification: Purified by Protein A/G

Immunogène: Human pheochromocytoma

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: PC12 cells. Adrenal gland, bowel, thyroid, pancreas or pheochromocytoma.

Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Chromogranin A

Antigène: Chromogranin A (CHGA)

Autre désignation: CHGA

Poids moléculaire: 68-75kDa

ID gène: 1113

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling