Cathepsin D anticorps (AA 104-250)

N° du produit ABIN6939218

L’anticorps Souris Monoclonal anti-Cathepsin D a été validé pour IHC, IF et StM. Il convient pour détecter Cathepsin D dans des échantillons de Humain.

Aperçu rapide pour Cathepsin D anticorps (AA 104-250) (ABIN6939218)

Antigène: Cathepsin D (CTSD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin D est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Staining Methods (StM)

Clone: CTSD-3276

Détail du produit anti-Cathepsin D anticorps

Épitope: AA 104-250

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment of human Cathepsin D protein (around aa 104-250) (exact sequence is proprietary)

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: MCF-7, K-562, A431 or SK-BR3 cells. Kidney, liver, lung or breast.

Known Application: Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Cathepsin D

Antigène: Cathepsin D (CTSD)

Autre désignation: CTSD

Sujet: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Poids moléculaire: 46kDa (Procathepsin D), 28kDa (Cathepsin D)

ID gène: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism