FcRn anticorps (AA 24-215)

N° du produit ABIN6939380

Cet anticorps anti-FcRn Monoclonal Souris (Clone FCGRT-2932) (ABIN6939380) détecte spécifiquement FcRn dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour FcRn anticorps (AA 24-215) (ABIN6939380)

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FcRn est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: FCGRT-2932

Détail du produit anti-FcRn anticorps

Épitope: AA 24-215

Fonction: FCGRT / FcRn (IgG Transporter) Antibody

Specificité: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human FCGRT protein (around aa 24-215) (Exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application:

Positive Control: THP1 or HepG2 cells. Cerebellum or Testis.

Known Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur FcRn

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Autre désignation: FCGRT

Sujet:

Fc fragment of IgG, receptor transporter, alpha, FCGRT, FCRN, alpha chain, IgG Fc fragment receptor transporter alpha chain, IgG Gc receptor, IgG receptor FcRn large subunit p51, Immunoglobulin receptor, intestinal, heavy chain, Neonatal Fc receptor

THP1 or HepG2 cells. Cerebellum or Testis.

Poids moléculaire: 46kDa

ID gène: 2217, 111903

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process