TOX3 anticorps (AA 251-389)

N° du produit ABIN6939531

L’anticorps Souris Monoclonal anti-TOX3 a été validé pour WB, ELISA et Coat. Il convient pour détecter TOX3 dans des échantillons de Humain.

Aperçu rapide pour TOX3 anticorps (AA 251-389) (ABIN6939531)

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TOX3 est non-conjugé

Application: Western Blotting (WB), ELISA, Coating (Coat)

Clone: TOX3-1124

Détail du produit anti-TOX3 anticorps

Épitope: AA 251-389

Specificité: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric Carcinoma.

Known Application: ELISA (For coating, order Ab without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur TOX3

Antigène: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Autre désignation: TOX3

Poids moléculaire: 63kDa

ID gène: 27324

UniProt: O15405

Pathways: Chromatin Binding