Gelsolin anticorps

N° du produit ABIN6939572

L’anticorps anti-Gelsolin Monoclonal Souris est utilisé pour la détection de Gelsolin dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour Gelsolin anticorps (ABIN6939572)

Antigène: Gelsolin (GSN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Gelsolin est non-conjugé

Application: Western Blotting (WB)

Clone: CPTC-Gelsolin-1

Détail du produit anti-Gelsolin anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant human full-length protein

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: MCF cell lysate, Tonsil.

Known Application: Western Blot (0.5-1.0 μg/mL), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Gelsolin

Antigène: Gelsolin (GSN)

Autre désignation: GSN

Sujet: Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5), also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Poids moléculaire: 90kDa

ID gène: 2934

UniProt: P06396

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization, Autophagy