Androgen Receptor anticorps (AA 151-350)

N° du produit ABIN6939804

Cet anticorps anti-Androgen Receptor est un anticorps Souris Monoclonal détectant Androgen Receptor dans IHC et StM. Adapté pour Humain.

Aperçu rapide pour Androgen Receptor anticorps (AA 151-350) (ABIN6939804)

Antigène: Androgen Receptor (AR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: DHTR-882

Détail du produit anti-Androgen Receptor anticorps

Épitope: AA 151-350

Specificité: Recognizes a protein of 110 kDa, which is identified as androgen receptor (AR). It reacts with full length, and the newly described A form of the receptor. It does not cross react with estrogen, progesterone, or glucocorticoid receptors. The expression of AR is reportedly inversely correlated with histologic grade i.e. well differentiated prostate tumors show higher expression than the poorly differentiated tumors. In prostate cancer, AR has been proposed, as a marker of hormone-responsiveness and thus it may be useful in identifying patients likely to benefit from anti-androgen therapy. Anti-androgen receptor has been useful clinically in differentiating morpheaform basal cell carcinoma (mBCC) from desmoplastic trichoepithelioma (DTE) in the skin.This MAb is superb for staining of formalin/paraffin tissues.

Aucune reactivité croisée: Souris

Purification: Purified by Protein A/G

Immunogène: Human DHTR recombinant protein fragment, aa151-350 (Exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Positive Control: LNCap cells. Prostate carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris buffer with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: Androgen Receptor (Marker of Androgen Dependence)

Poids moléculaire: 110kDa

ID gène: 367

UniProt: P10275

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding