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Recombinant Integrin beta 3 anticorps (AA 385-490)

ITGB3 Reactivité: Humain IHC, StM Hôte: Lapin Monoclonal ITGB3-2166R unconjugated Recombinant Antibody
N° du produit ABIN6939829
  • Antigène Voir toutes Integrin beta 3 (ITGB3) Anticorps
    Integrin beta 3 (ITGB3)
    Type d'anticorp
    Recombinant Antibody
    Épitope
    • 20
    • 16
    • 15
    • 13
    • 8
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 385-490
    Reactivité
    • 179
    • 94
    • 58
    • 17
    • 15
    • 13
    • 12
    • 10
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 117
    • 66
    • 13
    • 2
    • 2
    Lapin
    Clonalité
    • 112
    • 86
    Monoclonal
    Conjugué
    • 101
    • 16
    • 13
    • 12
    • 9
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Integrin beta 3 est non-conjugé
    Application
    • 129
    • 89
    • 51
    • 49
    • 31
    • 26
    • 24
    • 21
    • 15
    • 13
    • 13
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    Specificité
    Reacts with human integrin beta3 (GPIIIa, vitronectin receptor beta chain). It associates with the IIb-chain (CD41) to form the GpIIb/GpIIIa complex (CD41/CD61).The CD41/CD61 complex appears early in megakaryocyte maturation. The activated CD41/CD61 complex is a receptor for von Willebrand factor, soluble fibrinogen, fibronectin, vitronectin and thrombospondin. It plays a central role in platelet activation and aggregation. The CD51/CD61 is implicated in tumor metastasis and adenoviral infection. The antibody detects platelets in smears of blood and bone marrow, as well as megakaryocytes in frozen sections and cell smears. The antibody is useful for classification of megakaryoblastic leukemia.
    Purification
    Purified by Protein A/G
    Immunogène
    Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary)
    Clone
    ITGB3-2166R
    Isotype
    IgG
    Top Product
    Discover our top product ITGB3 Anticorps primaire
  • Indications d'application

    Positive Control: U937, KG1a, HEL cells. Spleen.

    Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.

    Restrictions
    For Research Use only
  • Concentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-80 °C
    Stockage commentaire
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Date de péremption
    24 months
  • Antigène
    Integrin beta 3 (ITGB3)
    Autre désignation
    ITGB3 (ITGB3 Produits)
    Synonymes
    anticorps BDPLT16, anticorps BDPLT2, anticorps CD61, anticorps GP3A, anticorps GPIIIa, anticorps GT, anticorps INGRB3, anticorps integrin, anticorps INTB3, anticorps GPIIIA, anticorps cd61, anticorps gp3a, anticorps itgb3, anticorps itgb3.2, anticorps itgb3.1, anticorps integrin subunit beta 3, anticorps integrin beta 3, anticorps integrin subunit beta 3 L homeolog, anticorps integrin beta 3a, anticorps integrin beta 3b, anticorps ITGB3, anticorps Itgb3, anticorps itgb3.L, anticorps itgb3a, anticorps itgb3b
    Poids moléculaire
    105kDa & 90kDa
    ID gène
    3690
    UniProt
    P05106
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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