RORC anticorps

N° du produit ABIN6940534

Détail du produit anti-RORC anticorps

Antigène: RORC (RAR-Related Orphan Receptor C (RORC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp RORC est non-conjugé

Application: ELISA, Coating (Coat)

Specificité: This MAb recognizes a protein of 63 kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR and ROR are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50 % amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors, due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors.

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human RORC protein

Clone: RORC-2942

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Positive Control: Human Lymphocytes. Liver or skeletal muscle tissue.

Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur RORC

Antigène: RORC (RAR-Related Orphan Receptor C (RORC))

Autre désignation: RORC (RORC Produits)

Synonymes: anticorps NR1F3, anticorps RORG, anticorps RZR-GAMMA, anticorps RZRG, anticorps TOR, anticorps Nr1f3, anticorps RORgamma, anticorps Thor, anticorps RAR related orphan receptor C, anticorps RAR-related orphan receptor C, anticorps RAR-related orphan receptor gamma, anticorps RORC, anticorps Rorc

Poids moléculaire: 63kDa

ID gène: 6097

UniProt: P51449

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway