SOX4 anticorps

N° du produit ABIN6940617

L’anticorps Souris Monoclonal anti-SOX4 a été validé pour IHC et StM. Il convient pour détecter SOX4 dans des échantillons de Humain.

Aperçu rapide pour SOX4 anticorps (ABIN6940617)

Antigène: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SOX4 est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: SOX4-2540

Détail du produit anti-SOX4 anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human SOX4 protein

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: Breast or Colon Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur SOX4

Antigène: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Autre désignation: SOX4

Sujet: SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF--induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival invitro and for primary tumor growth and metastasis invivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

Poids moléculaire: 47kDa

ID gène: 6659

UniProt: Q06945