Spectrin, Beta, Non-erythrocytic 2 (SPTBN2) (AA 356-475) anticorps

N° du produit ABIN6940652

Détail du produit

Antigène: Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

Épitope: AA 356-475

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Staining Methods (StM)

Purification: Purified by Protein A/G

Immunogène: Recombinant fragment (around aa356-475) of human SPTBN2 protein (exact sequence is proprietary)

Clone: SPTBN2-1583

Isotype: IgG2b kappa

Information d'application

Indications d'application:

Positive Control: PANC-1, HeLa cells. Pancreas or Liver.

Known Application: Flow Cytometry (1-2 μg/million cells), (,Immunofluorescence (0.5-1 μg/mL), ,Western Blot (0.5-1.0 μg/mL),Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détail du antigène

Antigène: Spectrin, Beta, Non-erythrocytic 2 (SPTBN2)

Autre désignation: SPTBN2 (SPTBN2 Produits)

Synonymes: anticorps Spnb3, anticorps mKIAA0302, anticorps GTRAP41, anticorps SCA5, anticorps spectrin beta, non-erythrocytic 2, anticorps spectrin, beta, non-erythrocytic 2, anticorps Sptbn2, anticorps SPTBN2

Sujet: Spectrin is an actin binding protein that is a major component of the plasma membrane skeleton. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Vertebrate spectrins have two alpha-subunits (alpha-I/alpha-II) four beta-subunits (beta-I-beta-IV) and a beta-H subunit creating diversity and specialization of function. Spectrin and spectrin are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin I (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Spectrin III is highly homologous to both spectrin I and spectrin II. Spectrin III is highly expressed in brain, kidney, pancreas and liver, and at lower levels in lung and placenta. Spectrin beta 3 is primarily expressed in nervous tissues with highest expression levels in the cerebellum, where it is found in Purkinje cell soma and dendrites.

Poids moléculaire: 246kDa

ID gène: 6712

UniProt: O15020

Pathways: Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis