TAL1 anticorps
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- Antigène Voir toutes TAL1 Anticorps
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TAL1 est non-conjugé
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Application
- ELISA, Coating (Coat)
- Purification
- Purified by Protein A/G
- Immunogène
- Recombinant human full-length TAL1 protein
- Clone
- TAL1-2707
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product TAL1 Anticorps primaire
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- Indications d'application
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Positive Control: A549 xenograft.
Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Antibody with azide - store at 2 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Date de péremption
- 24 months
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- Antigène
- TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))
- Autre désignation
- TAL1 (TAL1 Produits)
- Synonymes
- anticorps SCL/tal-1, anticorps Scl, anticorps bHLHa17, anticorps tal-1, anticorps SCL, anticorps TCL5, anticorps scl, anticorps tcl5, anticorps SCL-alpha, anticorps SCL-beta, anticorps scl/tal1, anticorps zgc:85605, anticorps T cell acute lymphocytic leukemia 1, anticorps TAL bHLH transcription factor 1, erythroid differentiation factor, anticorps T-cell acute lymphocytic leukemia 1 S homeolog, anticorps T-cell acute lymphocytic leukemia 1, anticorps Tal1, anticorps TAL1, anticorps tal1.S, anticorps tal1
- Sujet
- Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.
- Poids moléculaire
- 42kDa
- ID gène
- 6886
- UniProt
- P17542
- Pathways
- Stem Cell Maintenance
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