Recombinant Thyroglobulin anticorps

N° du produit ABIN6940713

L’anticorps Lapin Monoclonal anti-Thyroglobulin a été validé pour IHC et StM. Il convient pour détecter Thyroglobulin dans des échantillons de Humain.

Aperçu rapide pour Recombinant Thyroglobulin anticorps (ABIN6940713)

Antigène: Thyroglobulin (TG)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroglobulin est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: TGB-1970R

Détail du produit anti-Thyroglobulin anticorps

Aucune reactivité croisée: Souris, Rat (Rattus)

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human Thyroglobulin protein

Isotype: IgG

Information d'application

Indications d'application:

Positive Control: Thyroid.

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL, 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Thyroglobulin

Antigène: Thyroglobulin (TG)

Autre désignation: Thyroglobulin (Thyroidal Cell Marker)

Sujet: Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

Poids moléculaire: 660kDa (Dimeric Form)

ID gène: 7038

UniProt: P01266

Pathways: Thyroid Hormone Synthesis