CA8 anticorps

N° du produit ABIN6940916

L’anticorps Souris Monoclonal anti-CA8 a été validé pour IHC et StM. Il convient pour détecter CA8 dans des échantillons de Humain.

Aperçu rapide pour CA8 anticorps (ABIN6940916)

Antigène: CA8 (Carbonic Anhydrase VIII (CA8))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CA8 est non-conjugé

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: CPTC-CA8-2

Détail du produit anti-CA8 anticorps

Purification: Purified by Protein A/G

Immunogène: Recombinant full-length human CA8 protein

Isotype: IgG2a kappa

Information d'application

Indications d'application:

Positive Control: Human cerebellum. Selective expression in purkinje cells. HEK-293 and K-562 cell lines.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CA8

Antigène: CA8 (Carbonic Anhydrase VIII (CA8))

Autre désignation: CA8

Sujet: The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

Poids moléculaire: 32.97kDa

ID gène: 767

UniProt: P35219