ACTN2 anticorps (AA 557-692)

N° du produit ABIN6940978

Cet anticorps Souris Monoclonal détecte spécifiquement ACTN2 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ACTN2 anticorps (AA 557-692) (ABIN6940978)

Antigène: ACTN2 (Actinin, alpha 2 (ACTN2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ACTN2 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: ACTN2-3291

Détail du produit anti-ACTN2 anticorps

Épitope: AA 557-692

Fonction: Sarcomeric Actinin Alpha 2 / ACTN2 Antibody

Specificité: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: A recombinantfragment (aa557-692) ofhuman ACTN2 protein(exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application:

Positive Control: Skeletal orCardiac Muscle.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur ACTN2

Antigène: ACTN2 (Actinin, alpha 2 (ACTN2))

Autre désignation: ACTN2

Sujet:

Actin binding protein, Alpha actinin skeletal muscle, isoform 2, CMD1AA, F-actin cross-linking protein

Skeletal or Cardiac Muscle.

Poids moléculaire: 103kDa

ID gène: 88, 498178

UniProt: P35609

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity