Aggrecan anticorps

N° du produit ABIN6942053

Détail du produit anti-Aggrecan anticorps

Antigène: Aggrecan (ACAN)

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Aggrecan est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Réactivité croisée: Humain, Rat

Purification: Purified by Protein A.

Immunogène: C terminal human Aggrecan

Clone: 2F11

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur Aggrecan

Antigène: Aggrecan (ACAN)

Autre désignation: Aggrecan (ACAN Produits)

Synonymes: anticorps AGC1, anticorps AGCAN, anticorps CSPG1, anticorps CSPGCP, anticorps MSK16, anticorps SEDK, anticorps Agc, anticorps Agc1, anticorps Cspg1, anticorps b2b183Clo, anticorps cmd, anticorps aggrecan, anticorps aggrecan core protein, anticorps ACAN, anticorps Acan, anticorps LOC100380783, anticorps AGC

Sujet:

Synonyms: Aggrecan core protein, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, Aggrecan core protein 2, CSPCP, Chondroitin sulfate proteoglycan 1, ACAN, AGC1, CSPG1, MSK16

Background: The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.

ID gène: 176

UniProt: P16112

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport