Recombinant GABBR2 anticorps (AA 50-250)

N° du produit ABIN6943501

L’anticorps anti-GABBR2 Monoclonal Lapin est utilisé pour la détection de GABBR2 dans des échantillons de Humain. Il a été validé pour IF (p), IHC (p) et IHC (fro).

Aperçu rapide pour Recombinant GABBR2 anticorps (AA 50-250) (ABIN6943501)

Antigène: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GABBR2 est non-conjugé

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-GABBR2 anticorps

Épitope: AA 50-250

Fonction: GABBR2 Recombinant Antibody

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human GABA B Receptor 2 aa 50-250

Isotype: IgG

Information d'application

Indications d'application: IHC-P(IHC-P(1:50-200)), IHC-F(IHC-F(1:50-200)), IF(IHC-P)(IF(IHC-P)(1:50-200))

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur GABBR2

Antigène: GABBR2 (gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2))

Autre désignation: GABBR2

Sujet:

Synonyms: Gamma-aminobutyric acid type B receptor subunit 2, G-protein coupled receptor 51, GABA-B receptor 2, GABA B Receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, Gabbr2, Gm425, Gpr51.

Background: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).

ID gène: 9568

UniProt: O75899

Pathways: cAMP Metabolic Process