GLI3 anticorps

N° du produit ABIN6943536

Cet anticorps Lapin Monoclonal détecte spécifiquement GLI3 dans WB et IF (cc). Il présente une réactivité envers Humain.

Aperçu rapide pour GLI3 anticorps (ABIN6943536)

Antigène: GLI3 (GLI Family Zinc Finger 3 (GLI3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GLI3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 45G1

Détail du produit anti-GLI3 anticorps

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Recombinant protein within human Gli3 aa 1300-1600.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur GLI3

Antigène: GLI3 (GLI Family Zinc Finger 3 (GLI3))

Autre désignation: GLI3

Sujet:

Synonyms: Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3 full-length protein, Transcriptional repressor GLI3R, GLI3 C-terminally truncated form, GLI3 form of 83 kDa, GLI3-190, GLI3FL, GLI3-83,

Background: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.

ID gène: 2737

UniProt: P10071

Pathways: Signalisation Hedgehog