HNRNPC anticorps

N° du produit ABIN6943686

Cet anticorps Lapin Monoclonal détecte spécifiquement HNRNPC dans WB, IHC, IHC (p), IF (cc) et FACS. Il présente une réactivité envers Humain, Rat, Souris et Poisson zèbre (Danio rerio).

Aperçu rapide pour HNRNPC anticorps (ABIN6943686)

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Reactivité: Humain, Rat, Souris, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp HNRNPC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)

Clone: 9F7

Détail du produit anti-HNRNPC anticorps

Réactivité croisée: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Purification: Purified by Protein A.

Immunogène: Full length protein

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur HNRNPC

Antigène: HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC))

Autre désignation: hnRNP C1+C2

Sujet:

Synonyms: Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1/C2, HNRNPC

Background: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm6A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).

ID gène: 3183

UniProt: P07910