MUC4 anticorps

N° du produit ABIN6944168

Détail du produit anti-MUC4 anticorps

Antigène: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Réactivité croisée: Humain, Rat

Purification: Purified by Protein A.

Immunogène: C terminal Human MUC4

Clone: 3A1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 12 months

Détails sur MUC4

Antigène: MUC4 (Mucin 4, Cell Surface Associated (MUC4))

Autre désignation: MUC4 (MUC4 Produits)

Synonymes: anticorps 4933405I11Rik, anticorps Asgp, anticorps ASGP, anticorps HSA276359, anticorps MUC-4, anticorps ASGP-1, anticorps Psmc, anticorps mucin 4, anticorps mucin 4, cell surface associated, anticorps Muc4, anticorps MUC4

Sujet:

Synonyms: Mucin-4, Ascites sialoglycoprotein, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, Mucin-4 alpha chain, Ascites sialoglycoprotein 1, Mucin-4 beta chain, Ascites sialoglycoprotein 2, MUC-4, ASGP, ASGP-1, ASGP-2, MUC4

Background: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.

ID gène: 4585

UniProt: Q99102

Pathways: Regulation of Leukocyte Mediated Immunity