MYST1 anticorps (AA 351-450) (Biotin)

N° du produit ABIN6944205

Cet anticorps Lapin Polyclonal détecte spécifiquement MYST1 dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour MYST1 anticorps (AA 351-450) (Biotin) (ABIN6944205)

Antigène: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MYST1 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MYST1 anticorps (Biotin)

Épitope: AA 351-450

Réactivité croisée: Humain, Souris

Homologie: Rat,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human MYST1/KAT8

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur MYST1

Antigène: MYST1 (KAT8) (K(lysine) Acetyltransferase 8 (KAT8))

Autre désignation: MYST1/KAT8

Sujet:

Synonyms: EC 2.3.1.48, Histone acetyltransferase KAT8, Histone acetyltransferase MYST1, hMOF, K(lysine) acetyltransferase 8, KAT 8, Lysine acetyltransferase 8, MOF, MOZ, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, MYST 1, MYST histone acetyltransferase 1, myst protein 1, MYST-1, MYST1, MYST1_HUMAN, Ortholog of Drosophila males absent on the first (MOF), Probable histone acetyltransferase MYST1, SAS2 and TIP60 protein 1, SAS2, SAS3, TIP60 protein 1, YBF2, YBF2/SAS3.

Background: Dosage compensation ensures that males with a single X chromosome and females with two X chromosomes have the same amount of most X-linked gene products. In Drosophila, this is acheived by enhancing the level of transcription of the X chromosome in males. Proteins such as maleless, male specific lethal 1, 2 and 3, and males absent on the first (MOF) form a dosage compensation complex (DCC) that is required for the twofold increase of transcription of the male X chromosome. The DCC is preferentially associated with many sites on the X chromosome in somatic cells of males. The binding of the DCC to the X chromosome is dependent upon histone 4 acetylation at lysine 16, which is accomplished by MOF. In mammals, MOF (also designated hMOF, MYST1, or MOZ) belongs to the MYST family of histone acetyl transferases which are characterized by a unique C2HC-type zinc finger close to their HAT domains. MOF utilizes the zinc finger domain to contact the globular part of the nucleosome as well as the histone H4 N-terminal tail substrate. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone acetyltransferases.

ID gène: 84148

UniProt: Q9H7Z6