RPA2 anticorps
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- Antigène Voir toutes RPA2 Anticorps
- RPA2 (Replication Protein A2, 32kDa (RPA2))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp RPA2 est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Réactivité croisée
- Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- Recombinant protein within C-terminal human RPA32/RPA2.
- Clone
- 4F8
- Isotype
- IgG
- Top Product
- Discover our top product RPA2 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
IHC-P 1:200-400
IP(1-2 μg) - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- RPA2 (Replication Protein A2, 32kDa (RPA2))
- Autre désignation
- RPA2 (RPA2 Produits)
- Synonymes
- anticorps REPA2, anticorps RPA32, anticorps 153194_at, anticorps CG9273, anticorps Dmel\\CG9273, anticorps dRPA2, anticorps rpa, anticorps zgc:109822, anticorps ik:tdsubc_2g1, anticorps xx:tdsubc_2g1, anticorps repa2, anticorps rpa32, anticorps RPA2, anticorps GB13976, anticorps LOC100230445, anticorps AA409079, anticorps AI325195, anticorps AU020965, anticorps RPA34, anticorps Rf-A2, anticorps replication protein A2, anticorps Replication protein A2, anticorps replication protein A2, 32kDa, anticorps replication protein A 32 kDa subunit, anticorps RPA2, anticorps Rpa2, anticorps rpa2, anticorps LOC725418, anticorps RPA2_2
- Sujet
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Synonyms: Replication protein A 32 kDa subunit, RP-A p32, Replication factor A protein 2, Replication protein A 34 kDa subunit, RF-A protein 2, RP-A p34, RPA2, REPA2, RPA32, RPA34, Replication protein A2
Background: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
- ID gène
- 6118
- UniProt
- P15927
- Pathways
- Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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