SDCBP anticorps
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- Antigène Voir toutes SDCBP Anticorps
- SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp SDCBP est non-conjugé
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain
- Purification
- Purified by Protein A.
- Immunogène
- Recombinant protein within human Syntenin aa 1-200.
- Clone
- 2G6
- Isotype
- IgG
- Top Product
- Discover our top product SDCBP Anticorps primaire
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- Indications d'application
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
IP(1-2 μg) - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- SDCBP (Syndecan Binding Protein (Syntenin) (SDCBP))
- Autre désignation
- SDCBP (SDCBP Produits)
- Synonymes
- anticorps MDA-9, anticorps ST1, anticorps SYCL, anticorps TACIP18, anticorps Sycl, anticorps syntenin-1, anticorps mda-9, anticorps st1, anticorps sycl, anticorps tacip18, anticorps MGC81274, anticorps syntenin, anticorps wu:fc51c03, anticorps wu:fk31e01, anticorps zgc:55679, anticorps zgc:77716, anticorps sb:eu862, anticorps si:dkey-235k4.1, anticorps syndecan binding protein, anticorps syndecan binding protein L homeolog, anticorps syndecan binding protein (syntenin) 2, anticorps syndecan binding protein (syntenin), anticorps SDCBP, anticorps Sdcbp, anticorps sdcbp.L, anticorps LOC732879, anticorps sdcbp2, anticorps sdcbp
- Sujet
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Synonyms: Syntenin-1, Melanoma differentiation-associated protein 9, Pro-TGF-alpha cytoplasmic domain-interacting protein 18, Scaffold protein Pbp1, Syndecan-binding protein 1, MDA-9, TACIP18, SDCBP, MDA9, SYCL
Background: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer type. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
- ID gène
- 6386
- UniProt
- O00560
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