SMC1A anticorps (pSer957)

N° du produit ABIN6944922

Cet anticorps Lapin Monoclonal détecte spécifiquement SMC1A dans WB, IHC, IHC (p) et IF (cc). Il présente une réactivité envers Humain.

Aperçu rapide pour SMC1A anticorps (pSer957) (ABIN6944922)

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SMC1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 8H5

Détail du produit anti-SMC1A anticorps

Épitope: pSer957

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Synthetic phospho-peptide corresponding to residues surrounding Ser957 of human SMC1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SMC1A

Antigène: SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Autre désignation: SMC1

Sujet:

Synonyms: Structural maintenance of chromosomes protein 1A, Sb1.8, Structural maintenance of chromosomes protein 1B, SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B

Background: Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

ID gène: 8243

UniProt: Q14683

Pathways: Stem Cell Maintenance