SUN1 anticorps

N° du produit ABIN6945098

Cet anticorps anti-SUN1 est un anticorps Lapin Monoclonal détectant SUN1 dans WB, FACS, IHC (p), IF (cc) et IF (p). Adapté pour Humain et Rat.

Aperçu rapide pour SUN1 anticorps (ABIN6945098)

Antigène: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SUN1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 2C4

Détail du produit anti-SUN1 anticorps

Réactivité croisée: Humain, Rat

Purification: Purified by Protein A.

Immunogène: Recombinant protein corresponding to C-terminal human SUN1.

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur SUN1

Antigène: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Autre désignation: SUN1

Sujet:

Synonyms: SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1, SUN1, KIAA0810, UNC84A

Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.

ID gène: 23353

UniProt: O94901

Pathways: Maintenance of Protein Location