tau anticorps (PE)

N° du produit ABIN6952109

Cet anticorps Souris Monoclonal détecte spécifiquement tau dans WB, ELISA, IF, ICC et DB. Il présente une réactivité envers Humain.

Aperçu rapide pour tau anticorps (PE) (ABIN6952109)

Antigène: tau (tau Protein)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp tau est conjugé à/à la PE

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Dot Blot (DB)

Clone: 1D5

Détail du produit anti-tau anticorps (PE)

Specificité: Expressed in neurons.,Detects Multiple Bands. Antibody detects monomer under denaturing conditions but preferentially detects fibril under native conditions (dot blot).

Réactivité croisée: Humain, Souris

Purification: Protein G Purified

Immunogène: Human Recombinant Tau441 (2N4R), P301S mutant Protein Pre-formed Fibrils

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:1000 dilution of ABIN6952109 was sufficient for detection of Tau 2N4R P301S Fibril in 20 ug of Mouse Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % Sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur tau

Antigène: tau (tau Protein)

Autre désignation: Tau

Sujet: Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). 2N4R, or Tau-441 is the full length tau protein. P301S is a mutation encoded by exon 10 (4) that impairs the ability of tau to assemble microtubules (5).

NCBI Accession: NP_005901

UniProt: P10636