CBFB anticorps

N° du produit ABIN6952396

Cet anticorps anti-CBFB est un anticorps Lapin Polyclonal détectant CBFB dans ELISA, ChIP et ChIP-seq. Adapté pour Humain.

Aperçu rapide pour CBFB anticorps (ABIN6952396)

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFB est non-conjugé

Application: ELISA, Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Détail du produit anti-CBFB anticorps

Specificité: Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH-conjugated synthetic peptides containing sequences from the central region of the protein.

Purification: whole antiserum

Immunogène: synthetic peptide

Information d'application

Indications d'application: ChIP 4 μL:ChIP
ELISA 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: serum, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur CBFB

Antigène: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Autre désignation: CBFb

Sujet: CBFb (UniProtKB/Swiss-Prot entry Q13951) represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukaemia of the M4Eo subtype

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha