NK-1.1/CD161c anticorps

N° du produit ABIN6961464

Détail du produit anti-NK-1.1/CD161c anticorps

Antigène: NK-1.1/CD161c (NK-1.1)

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NK-1.1/CD161c est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.

niveau d'endotoxine: Low endotoxin: < 0.01 EU/ug

Clone: PK136

Isotype: IgG2a kappa

Information d'application

Indications d'application: This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.

Commentaires:

2 mg/mL

Restrictions: For Research Use only

Stockage

Buffer: 10 mM NaH2PO4, 150 mM NaCl, pH 7.2

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: 2-8°C

Date de péremption: 12 months

Détails sur NK-1.1/CD161c

Antigène: NK-1.1/CD161c (NK-1.1)

Autre désignation: NK1.1 (CD161) (NK-1.1/CD161c Produits)

Synonymes: anticorps AI462337, anticorps CD161, anticorps Ly-59, anticorps Ly55c, anticorps Ly59, anticorps NK-RP1, anticorps NK1.1, anticorps NKR-P1.9, anticorps NKRP1, anticorps NKRP140, anticorps Nk-1, anticorps Nk-1.2, anticorps Nk1, anticorps Nk1.2, anticorps Nkrp1c, anticorps ly-55c, anticorps killer cell lectin-like receptor subfamily B member 1C, anticorps Klrb1c

Sujet: The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1. (Ehlers et al. 2012. Endocrinology. 10: 1247.)The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).

ID gène: 17059

UniProt: P27814