APOE anticorps

N° du produit ABIN6963937

Cité dans 5 publications. Cet anticorps anti-APOE Monoclonal Souris (Clone E276) (ABIN6963937) détecte spécifiquement APOE dans WB, ELISA et ELISpot. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour APOE anticorps (ABIN6963937)

Antigène: APOE (Apolipoprotein E (APOE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOE est non-conjugé

Application: Western Blotting (WB), ELISA, ELISpot

Clone: E276

Détail du produit anti-APOE anticorps

Specificité: Native and recombinant human apolipoprotein E (isoforms apoE2, apoE3 and apoE4).

Purification: Purified from in vitro cultures by protein G affinity chromatography.

Immunogène: Purified human apolipoprotein E

Isotype: IgG1

Information d'application

Indications d'application: For quantification of apoE in serum/plasma samples and cell culture supernatants using ELISA and for enumeration of apoE producing cells using ELISpot. E276 is recommended as coating mAb in combination with detection mAb E887 . The antibody is also suitable for immunoprecipitation and Western blot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: supplied at 0.5 mg/mL in PBS with 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.

Date de péremption: 18 months

Références pour anticorps anti-APOE (ABIN6963937)

van Harten, Jongbloed, Teunissen, Scheltens, Veerhuis, van der Flier: "CSF ApoE predicts clinical progression in nondemented APOEε4 carriers." dans: Neurobiology of aging, Vol. 57, pp. 186-194, (2018) (PubMed).

Bissig-Choisat, Wang, Legras, Saha, Chen, Bell, Pankowicz, Hill, Barzi, Leyton, Leung, Kruse, Himes, Goss, Wilson, Chan, Lagor, Bissig: "Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model." dans: Nature communications, Vol. 6, pp. 7339, (2015) (PubMed).

Braesch-Andersen, Paulie, Smedman, Mia, Kumagai-Braesch: "ApoE production in human monocytes and its regulation by inflammatory cytokines." dans: PLoS ONE, Vol. 8, Issue 11, pp. e79908, (2014) (PubMed).

Handattu, Nayyar, Garber, Palgunachari, Monroe, Keenum, Mishra, Datta, Anantharamaiah: "Two apolipoprotein E mimetic peptides with similar cholesterol reducing properties exhibit differential atheroprotective effects in LDL-R null mice." dans: Atherosclerosis, Vol. 227, Issue 1, pp. 58-64, (2013) (PubMed).

Liu, Kuhel, Shen, Hui, Woods: "Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice." dans: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 303, Issue 9, pp. R903-8, (2013) (PubMed).

Détails sur APOE

Antigène: APOE (Apolipoprotein E (APOE))

Autre désignation: apoE

ID gène: 348

Pathways: Regulation of Cell Size, Lipid Metabolism