BUB1 anticorps (AA 281-419)

N° du produit ABIN6971474

Cet anticorps Souris Monoclonal détecte spécifiquement BUB1 dans IF et ICC. Il présente une réactivité avec des échantillons de Humain et Souris.

Aperçu rapide pour BUB1 anticorps (AA 281-419) (ABIN6971474)

Antigène: BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BUB1 est non-conjugé

Application: Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 14H5

Détail du produit anti-BUB1 anticorps

Épitope: AA 281-419

Attributs du produit: Bub1 is a serine-threonine protein kinase and an important regulator of cell division. It is essential for the G2/M mitotic spindle assembly/integrity checkpoint as well as critical for chromosome alignment. Bub1 is required for the assembly of a large number of proteins at the kinetochore, including CENP-E, CENP-F, BUB1B, MAD2L1 and PLK1. It plays a role in sister chromatid cohesion and it serves as a substrate for the anaphase-promoting complex. Bub1 mediates cell death in response to chromosome mis-segregation and acts to suppress spontaneous tumorigenesis. Bub1 antibody (mAb) (Clone 14H5) was raised in a Mouse host. It has been validated for use in Immunocytochemistry and Immunofluorescence, it has been shown to react with Human and Mouse samples.

Purification: Protein G Chromatography

Immunogène: This Bub1 antibody was raised against a recombinant protein corresponding to amino acids 281-419 of human Bub1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur BUB1

Antigène: BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))

Autre désignation: Bub1

Poids moléculaire: 130 kDa

NCBI Accession: NP_004327