RAR-alpha (AA 428-441) anticorps

N° du produit ABIN6972585

L’anticorps anti-RAR-alpha Monoclonal Souris est utilisé pour la détection de RAR-alpha dans des échantillons de Humain. Il a été validé pour IHC, SSA et WB.

Aperçu rapide pour RAR-alpha (AA 428-441) anticorps (ABIN6972585)

Antigène: RAR-alpha

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Supershift Assay (SSA), Western Blotting (WB)

Clone: 4gamma-7A11

Détail du produit

Épitope: AA 428-441

Attributs du produit: Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-g has two splice isoforms. RAR-g heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with co-repressor protein. Binding of agonist ligands to RAR results in dissociation of co-repressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein. RAR-gamma antibody (mAb) (Clone 4g-7A11) was raised in a Mouse host. It has been validated for use in Immunohistochemistry, Supershift and Western blot, it has been shown to react with Human samples.

Purification: Protein G Chromatography

Immunogène: This RAR-γ antibody was raised against a recombinant protein corresponding to amino acids 428-441 (F-region) of human RARγ.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détail du antigène

Antigène: RAR-alpha

Autre désignation: RAR-γ

Poids moléculaire: 52 kDa

NCBI Accession: NP_000957