YAP1 anticorps (C-Term)

N° du produit ABIN6972915

Détail du produit anti-YAP1 anticorps

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YAP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Attributs du produit: YAP1 (Yes-associated protein 1, YAP, YKI, YAP2, YAP65) is a transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. Is a critical modulator of epidermal stem cell proliferation. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. YAP1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.

Purification: Affinity Purified

Immunogène: This YAP1 antibody was raised against a peptide corresponding to the C-terminal region of human YAP1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Détails sur YAP1

Antigène: YAP1 (Yes-Associated Protein 1 (YAP1))

Autre désignation: YAP1 (YAP1 Produits)

Synonymes: anticorps YAP, anticorps YAP2, anticorps YAP65, anticorps YKI, anticorps xyap, anticorps yap, anticorps yap2, anticorps yap65, anticorps yki, anticorps AI325207, anticorps Yap, anticorps Yap65, anticorps Yki, anticorps Yorkie, anticorps cb194, anticorps sb:cb194, anticorps si:ch211-181p1.5, anticorps si:dkey-3b8.3, anticorps wu:fc18c04, anticorps zgc:158380, anticorps Yes associated protein 1, anticorps Yes associated protein 1 S homeolog, anticorps yes-associated protein 1, anticorps Yes-associated protein 1, anticorps YAP1, anticorps yap1.S, anticorps Yap1, anticorps yap1

Poids moléculaire: 75 kDa

NCBI Accession: NP_001123617

Pathways: Signalisation MAPK, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha