Importin 5 anticorps (AA 501-600) (AbBy Fluor® 488)

N° du produit ABIN6977507

L’anticorps Lapin Polyclonal anti-Importin 5 a été validé pour IF (cc) et IF (p). Il convient pour détecter Importin 5 dans des échantillons de Rat.

Aperçu rapide pour Importin 5 anticorps (AA 501-600) (AbBy Fluor® 488) (ABIN6977507)

Antigène: Importin 5 (IPO5)

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Importin 5 est conjugé à/à la AbBy Fluor® 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Importin 5 anticorps (AbBy Fluor® 488)

Épitope: AA 501-600

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Karyopherin beta 3

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Importin 5

Antigène: Importin 5 (IPO5)

Autre désignation: Karyopherin beta 3

Sujet:

Synonyms: DKFZp686O1576, FLJ43041, IMB3, Imp5, Importin 5, Importin beta 3 subunit, Importin subunit beta 3, Importin subunit beta-3, Importin-5, IPO 5, IPO5, IPO5_HUMAN, Karyopherin beta 3, Karyopherin beta-3, KPNB3, MGC2068, Pse1, Ran binding protein 5, Ran GTP binding protein 5, Ran-binding protein 5, RanBP 5, RanBP5.

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

ID gène: 3843

UniProt: O00410

Pathways: Protein targeting to Nucleus